Below are the first statewide softball rankings of the 2021 season as compiled by the Missouri High School Fastpitch Coaches Association.

Class 5

(As of 9/10)
1. Rock Bridge
2. Blue Springs South
3. Liberty
4. Blue Springs
5. Francis Howell Central
6. Raymore-Peculiar
T-7. Cape Notre Dame
T-7. Staley
9. Lee’s Summit North
10. Grain Valley
Others receiving votes: Eureka, Helias, Jackson, Liberty North, Nixa, Oakville, Troy

Class 4

(As of 9/10)
1. Rockwood Summit
2. Capital City
3. Farmington
4. Smithville
5. Washington
6. Rolla
7. Webb City
8. Warrensburg
9. Platte County
10. Neosho
Others receiving votes: Hillsboro, McDonald County, Incarnate Word

Class 3

(As of 9/10)
1. Rogersville
2. Blair Oaks
3. Sullivan
4. Fulton
5. Bowling Green
6. Hallsville
7. Macon
8. Holden
9. Chillicothe
10. Southern Boone
Others receiving votes: Fatima, Versailles

Class 2

(As of 9/10)
1. Sherwood
2. Russellville
3. Carrollton
4. Marceline
5. Fayette
6. Iberia
7. Monroe City
8. Palmyra
9. New Bloomfield
10. Elsberry

Class 1

(As of 9/13)
1. Jefferson
2. Canton
3. St. Elizabeth
4. Marion C. Early
5. Maysville
6. North Andrew
7. Vienna
T-8. Nellyville
T-8. LaPlata
T-10. Polo
T-10. East Carter
Others receving votes: Atlanta, Naylor