Here are the top players in rushing yardage for the 2021 football season.
A player had to have at least 1,000 yards rushing and be a player on a full member MSHSAA team to make this list.
We compiled this list by contacting coaches and getting numbers for area players. If you know of a player who is missing, please have their coach email at stats@ky3.com with the information.
NOTE: THIS IS A RANKINGS BASED SOLELY ON TOTAL YARDS RUSHING. THESE ARE NOT SUBJECTIVE.
| Rank | Name | School | Yards | Carries | Touchdowns | YPC |
| 1 | Luke Gall | Carthage | 1,902 | 166 | 29 | 11.5 |
| 2 | Avious Steadman | Nevada | 1,831 | 154 | 23 | 11.9 |
| 3 | Brady Slavens | Warsaw | 1,748 | 179 | 19 | 9.8 |
| 4 | Cade Muscia | Lebanon | 1,724 | 315 | 27 | 5.5 |
| 5 | Dakota Wilson | Marionville | 1,648 | 216 | 35 | 7.6 |
| 6 | Corgan Strong | Forsyth | 1,644 | 249 | 24 | 6.6 |
| 7 | Ricky Woodhouse | Skyline | 1,627 | 244 | 23 | 6.7 |
| 8 | Blake Russell | Hollister | 1,601 | 159 | 16 | 10.1 |
| 9 | Cade Wilson | Webb City | 1,556 | 211 | 27 | 7.4 |
| 10 | Jackson Willison | Thayer | 1,547 | 247 | 20 | 6.3 |
| 11 | Layne Colvin | Stockton | 1,523 | 206 | 12 | 7.4 |
| 12 | Braxton Davis | Cabool | 1,386 | 243 | 16 | 5.7 |
| 13 | Jackson Marrs | Seneca | 1,383 | 209 | 17 | 6.6 |
| 14 | Brock Mooneyham | Ash Grove | 1,364 | 182 | 21 | 7.5 |
| 15 | Eric Richardson | Waynesville | 1,332 | 165 | 12 | 8.1 |
| 16 | Avery Moody | Republic | 1,285 | 191 | 20 | 6.7 |
| 17 | Kody Stacye | Fair Grove | 1,274 | 128 | 17 | 10.0 |
| 18 | Jaxson Graham | Seneca | 1,269 | 170 | 12 | 7.5 |
| 19 | Clayten O’Hara | Pierce City | 1,264 | 184 | 16 | 6.9 |
| 20 | Joel Beshore | Lamar | 1,264 | 184 | 14 | 6.9 |
| 21 | Dayvion Harris | Marshfield | 1,248 | 166 | 13 | 7.5 |
| 22 | Jared Siler | Neosho | 1,226 | 225 | 14 | 5.4 |
| 23 | Ian Jackson | Aurora | 1,200 | 167 | 13 | 7.2 |
| 24 | Dagen Kenslow | West Plains | 1,184 | 120 | 9 | 9.9 |
| 25 | Hunter Shallenburger | Diamond | 1,179 | 169 | 14 | 7.0 |
| 26 | Hunter Adams | Ava | 1,174 | 165 | 25 | 7.1 |
| 27 | Brett Schwanke | Buffalo | 1,168 | 140 | 9 | 8.3 |
| 28 | Nathan Bartel | Lebanon | 1,148 | 115 | 12 | 10.0 |
| 29 | Keelan Jordan | Bolivar | 1,117 | 226 | 8 | 4.9 |
| 30 | Hayden Fane | Rolla | 1,094 | 170 | 11 | 6.4 |
| 31 | Dupree Jackson | Webb City | 1,028 | 137 | 19 | 7.5 |
| 32 | JJ O’Neal | Rogersville | 1,025 | 111 | 14 | 9.2 |
| 33 | Cole Martin | Mac County | 1,015 | 149 | 17 | 6.8 |
| 34 | Landon Clement | Diamond | 1,005 | 224 | 8 | 4.5 |
