Below is the Class 4 All-Region girls cross country team as voted on by the Southwest Cross Country Coaches Association.
Athlete of the Year: Abigail Street, Webb City
Coach of the Year: Rhett Cook, Rolla
| 1st Team | ||
| Abigail Street | Webb City | 12 |
| Isabella Frost | Rolla | 12 |
| Rebecca Waterman | Parkview | 12 |
| Ayden Spotila | Bolivar | 11 |
| Emma Howes | Bolivar | 9 |
| Emily Ritter | West Plains | 9 |
| Addison Sanders | West Plains | 10 |
| Jordan Tollenaar | West Plains | 12 |
| 2nd Team | ||
| Kathryn Hirtz | Rolla | 11 |
| Avery Morris | Nevada | 12 |
| Kaylea Dixon | West Plains | 12 |
| Brooke Hedger | Webb City | 9 |
| Bridget Ragan | Rolla | 11 |
| Aisley James | Logan Rogersville | 11 |
| Kendall Langley | Rolla | 9 |
| Honorable Mention | ||
| Rachel Miller | Webb City | 10 |
| Emma Dixon | West Plains | 9 |
| Tessa Ludden | Bolivar | 9 |
| Seri King | West Plains | 9 |
| Allie Rains | Nevada | 12 |
| Lindsey Parkin | Hillcrest | 11 |
| Daphnie Dollins | West Plains | 12 |
| Mary Jastal | Monett | 10 |
| Emily Countryman | Webb City | 11 |
